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Image Search Results
Journal: Blood
Article Title: SOX11 augments BCR signaling to drive MCL-like tumor development
doi: 10.1182/blood-2018-02-832535
Figure Lengend Snippet: SOX11 expression leads to clonal expansion of B cells. (A) Deep sequencing of the genomic DNA from B1a cells showing increased IgH gene clonality in Tg-SOX11 mice vs WT mice. (B) Decreased total productive rearrangements in the BCR repertoire of B1a cells of Tg-SOX11 mice vs WT mice showing a decrease in IgH gene diversity. (C) Frequency of the top 10 rearrangements compared with all other rearrangements of the IgH locus in B1a cells showing clonality in 2 Tg-SOX11 mice and oligoclonality in 2 Tg-SOX11 mice vs normal IgH diversity in the 2 WT mice. (D) Productive frequency of the top 100 IgH gene rearrangements shows loss of IgH diversity in all Tg-SOX11 mice (N = 4) as compared with WT mice (N = 2). In the histogram, each color represents a unique IgH clone, whereas the numerals represent the frequency of top clone in each mouse.
Article Snippet: We conducted next-generation deep sequencing of the genomic
Techniques: Expressing, Sequencing
Journal: Mammalian Genome
Article Title: Genome characterization of the selected long- and short-sleep mouse lines
doi: 10.1007/s00335-016-9663-6
Figure Lengend Snippet: Differences between ILS and ISS strains: Variant Breakdown. a Combined totals of variants that differ between the ILS and ISS strains. Synonymous mutations refer to a SNP(s) that alters the codon sequence but not the amino acid produced. Synonymous and non-synonymous mutations arise from the impact of a SNP on the underlying codon. Frameshifts are any indel not divisible by three, whereas deletions and insertions retain the reading frame. Variants are counted once per gene. b Combined totals of structural variations that differ between ILS and ISS strains. Losses and gains refer to changes in copy number, whereas a deletion is a complete loss/absence of a region. Chromosomal translocations refer to exchanges of large segments between chromosomes and inversions are reversals. c Distribution of structural variations by type, summarized by a sliding window approach (500 k windows with 100 k step size) (Color figure online)
Article Snippet: However, technological and analytical advances, including high-throughput gene expression analysis and “Next-Generation”
Techniques: Variant Assay, Sequencing, Produced